The Revenant from Doom 3 has IMO the best monster design out of any game or other I've seen.
You can create as many variations of a medieval dragon as you'd like but in the end it'll still be a boring old dragon. Or you can copy trolls and make them as big as you'd like but they'll still be a cyberdemon.
The Revenant is a rocket-backpack-laucher wielding skeleton with a semi-translucent skin that makes terrifying growls and has a very damaging claw attack. That's originality you don't see often.
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